| Corneal infiltrates are part of the expected spectrum of anterior segment eye disease, but as these localized opacifications of normally transparent corneal tissue can be either “sterile” corneal inflammation or active microbial infections, they become an issue of some concern.The appearance of corneal infiltrates, in particular in association with contact lens wear, should always increase the clinician’s suspicion of direct corneal infection. The clinician must make a decision to diagnose and treat a corneal infection or a non-infectious over active immune response. This decision is far from trivial, as there is no clear cut boundary, and inappropriate treatment of an active corneal infection may be disastrous for the patient. |